Ron Gutman, founder and CEO of digital-health startup HealthTap, dares entrepreneurs to enjoy, not just endure, the journey by doing something that matters deeply to many people. A serial entrepreneur, inventor and big believer in the power of positivity, Gutman also describes how the heart of success is understanding human need at a granular level.

Sean George, president and chief operating officer of genetics-information company Invitae, explains how the rewards of entrepreneurship come from facing the major challenges along the way. In this insightful talk, the serial entrepreneur also underscores the necessity of a team’s focus on mission to see a venture through adversity.

Laurene Powell Jobs, in conversation with Stanford Engineering Professor Tom Byers, shares her path to entrepreneurship and her strong commitment to addressing massive challenges in education and immigration reform through College Track and Emerson Collective, organizations she founded to spark systemic change and improve lives at the individual level.

Kathryn Gould, one of the first women venture capitalists in Silicon Valley, shares what she’s learned after many years of picking successful startups and forging her own career path. In conversation with tech-industry author and journalist Mike Malone, the co-founder of Foundation Capital tells entrepreneurs to identify a true target customer and market opportunity, and be prepared to give 100 percent.

Alon Cohen, co-founder and president of Houzz, a leading platform for home remodeling and design, shares insights on being an immigrant entrepreneur in Silicon Valley, and how the drive to work hard and persevere are more essential than mere talent. Cohen explains that success rests on building products that are both useful and simplify complicated tasks.

National Geographic Explorer Shah Selbe describes how much Earth needs technologists with an entrepreneurial spirit to address global challenges and conserve the planet’s resources. A spacecraft-propulsion engineer by training, Selbe shares profound experiences from expeditions in the wild and calls on the next wave of innovators to find their passion and realize that opportunities exist everywhere.